Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta
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چکیده
منابع مشابه
Regulation of MT1-MMP/MMP-2/TIMP-2 axis in human placenta
Matrix metalloproteinases (MMPs) and specific endogenous tissue inhibitors of metalloproteinases (TIMPs) mediate rupture of the fetal membranes in both physiological and pathological conditions. MMPs and TIMPs are subject to regulation by DNA methylation in human malignancies and pre-eclampsia. To determine if membrane type 1 MMP (MT1-MMP), MMP2, and TIMP2 are regulated by DNA methylation in hu...
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Macrophage migration inhibitory factor (MIF) is an important proinflammatory cytokine involved in regulation of macrophage function. In addition, MIF may also play a role in murine and human reproduction. Although both first trimester trophoblast and decidua express MIF, the regulation and functional significance of this cytokine during human placental development remains unclear. We assessed M...
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OBJECTIVE To determine the transfer of 2-naphthol (2-NPH) in fullterm human placental tissues. METHODS Six placentas were studied. The ex-vivo dual closed-loop human placental cotyledon perfusion model was used. 2-NPH was added to the perfusate in the maternal compartment. Samples were obtained from the maternal and fetal up to 360 min measuring. RESULTS The mean fetal weight was 2880 ± 304...
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ژورنال
عنوان ژورنال: Journal of Inflammation Research
سال: 2015
ISSN: 1178-7031
DOI: 10.2147/jir.s88039